Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters
نویسندگان
چکیده
منابع مشابه
Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide.
We recently reported a novel interaction between Bcl-2 and Rac1 and linked that to the ability of Bcl-2 to induce a pro-oxidant state in cancer cells. To gain further insight into the functional relevance of this interaction, we utilized computer simulation based on the protein pathway dynamic network created by Cellworks Group Inc. STAT3 was identified among targets that positively correlated ...
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15 صفحه اولThe expression of antiapoptotic proteins Bcl-2, Bcl-X(L), and Mcl-1 in benign, dysplastic, and malignant biliary epithelium.
AIM Cholangiocarcinoma can be cured by surgery, but only in a minority of cases. The activation of apoptosis is a major mode of action of chemotherapy and radiotherapy, which have limited benefit in the treatment of cholangiocarcinoma. The antiapoptotic members of the Bcl-2 protein family (Bcl-2, Bcl-X(L), and Mcl-1) are important inhibitors of apoptosis, but have not been investigated extensiv...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2000
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400656